 InvitationIt is our pleasure to
invite you to participate at the 1st International
Symposium on Genetic and Immune Correlates of HIV Infection and Vaccine-Induced Immunity,
to be held in Budapest, Hungary, 10-13 of June, 2007.
The necessity and timeliness of such a congress are justified by the numerous unresolved issues in developing a successful HIV vaccine that could halt the relentless spread of HIV/AIDS. One reason for the failures to date is the lack of validated immune correlates of vaccine efficacy, predicting long-term protection against the virus. Namely, there is increasing evidence that the traditional tests (CTL, neutralizing antibodies), or their variations, may not provide reliable efficacy markers, it is time to consider and evaluate non-traditional, alternative immunological methods as well. The cases of exposed-uninfected individuals, along with clear evidence for the existence of natural anti-HIV immunity, still represent useful resources for potentially important clues in this area. Another unexplored area in AIDS vaccine research is the genetic correlates of immune response and disease progression, which too might hold precious information for our progress. For all these reasons, the János Szentágothai Knowledge Center of Semmelweis University, and the Vaccine Therapy Cluster in Budapest, in conjunction with many sponsoring organizations in Hungary, has initiated the present conference with the ambitious agenda to bring together prominent scientists, the best experts in this field.
Invited speakers Alving, Carl (Rockville, MD, USA) Borkowsky, William (New York, NY, USA) Blumenthal, Robert (Frederick, MD, USA) Chiodi, Francesca (Stockhom, Sweden) Clerici, Mario (Milan, Italy) Dandekar, Satya (Davis, CA, USA) Rivera, Daniel S. (Providence, RI, USA) Dierich, Manfred (Innsbruck, Austria) Füst, George (Budapest, Hungary) Greene, Warner C. (San Francisco, CA, USA) Kotwal, Girish (Cape Town, South Africa) Koup, Richard A. (Bethesda, MD, USA) Lehner, Thomas (London, UK) Lisziewicz, Julianna (Washington, DC, USA and Budapest, Hungary) Lévy, Yves (Créteil, France) Lori, Franco (Pavia, Italy) Lusso, Paolo. (Milan, Italy) Mehra, Narinder (New Delhi, India) Miyazawa, Masaaki (Osaka, Japan) O’Brien, Stephen J. (Frederick, MD, USA) Pantaleo, Guiseppe (Lausanne) Sattentau, Quentin J. (Oxford, UK) Veas, Francisco (Montpellier, France) Veljkovic, Veljko (Belgrade, Serbia and Montenegro) Wyatt, Richard (Bethesda, MD, USA)
Organizing Committee Alving, Carl (Rockville) Clerici, Mario (Milan) Füst, George (Budapest) co-chair of the conference Horban, Andrzej (Warsaw) Lehner, Thomas (London) Kazatchkine, Michel (Paris) Lisziewicz, Julianna (Washington-Budapest) co-chair of the conference Mayer, Vlastimil (Bratislava) Sedlacek, Dalibor (Plzen) Szebeni, János (Rockville-Budapest) - secretary Ujhelyi, Eszter (Budapest)
Sunday, 10th June 18:00 Opening ceremony Chairpersons: Lisziewicz, J., Füst, G. 19:00 Keynote lecture: Pantaleo, G. (Lausanne, Switzerland): Functional signatures of protective antiviral T-cell immunity: A guide to the development of vaccine strategies 20:00 Welcome reception
Monday, 11th June 8:30-12:00 Oral Section Topic 1: Genetics Chairpersons: Lehner, T., O’Brien, S. 8:30 T1-INV-1 - O’Brien, S. (Frederick, MD, USA): Genetic architecture of complex infectious diseases: Lessons from AIDS 9:00 T1-INV-2 - Mehra, N. (New Delhi, India): Genetic basis of HIV-1 susceptibility, transmission and progression to AIDS in North Indians 9:30 T1-INV-3 - Miyazawa, M. (Osaka, Japan): Host genes controlling immune responses to retroviral infections and genetic correlates of HIV-1-exposed but uninfected status
10:00 Coffee break
10:20 T1-IN-4 - Rivera, D. (Providence, RI, USA): The GAIA HIV vaccine: An epitope-driven globally relevant HIV vaccine - Progress to date 10:50 T1-SO-1 - Tiemessen, C. (Johannesburg, South Africa): Host CCL3 genotype influences the development and maintenance of HIV-specific T cell responses associated with control of infection 11:00 T1-SO-2 - Nagy, K. (Budapest, Hungary): HIV pseudovirion assay for viral coreceptor selection and entry fitness 11:10 T1-SO-3 – Lukashov, V. (Amsterdam, The Netherlands): The role of human genetic factors in the immune control of HIV-1: analysis of a unique cohort of a single-source HIV-1 outbreak eliminates confounding effects of virus genetic diversity 11:20 Discussion
12:00-13:00 Lunch break
13:00 Poster viewing 13:15 Poster discussion Chairpersons: Nagy, K., Mayer, V.
14:00-19:00 Oral section Topic 2: Immunology Chairpersons: Koup, R., Lusso, P. 14:00 T2-INV-1 - Lehner, T. (London, UK): In vivo induction of APOBEC3G innate antiviral factor, expressed in CD4+ memory T cells 14:30 T2-INV-2 - Clerici, M. (Milan, Italy): Correlates of resistance to HIV infection 15:00 T2-INV-3 - Koup, R. (Bethesda, MD, USA): Defining T cell functions associated with immune protection
15:30 Coffee break
15:50 T2-INV-4 - Lusso, P. (Milan, Italy): HIV and chemokines: Implications for pathogenesis, prevention and treatment 16:20 T2-INV-5 - Greene, W. (San Francisco, CA, USA): Deciphering the diverse actions of the anti-HIV factor, APOBEC3G 16:50 T2-INV-6 - Chiodi, F. (Stockholm, Sweden): B cell responses during HIV-1 infection: serologic memory and B cell homing 17:20 T2-SO-1 - Rinaldo, C. (Pittsburgh, PA, USA): Primary CD8+ T cell responses to immune escape variants of HIV-1 17:30 T2-SO-2 - Bofill, M. (Badalona, Spain): Increased percentage of CD4 T- cells expressing IL-12Rbeta1 and IL-18Ralpha in HIV-1 infection: a potential compensatory mechanism for the loss of Th1 response 17:40 T2-SO-3 - Rethi, B. (Stockholm, Sweden): Regulation of T cell homeostasis by Interleukin-7 and Fas in HIV-infected individuals 17:50 T2-SO-4 - Ganusov, V. (Utrecht, The Netherlands): Estimating costs and benefits of CTL escape mutations in HIV/SIV infection 18:00 T2-SO-5 - Voltersvik, P. (Bergen, Norway): Expression of the cysteine proteinase Cathepsin B and its inhibitor Cystatin A in tonsillar germinal centres during HIV-1 infection and HAART 18:10 Discussion
Tuesday, 12th June 8:45-12:30 Oral section Topic 3: Lipids Chairpersons: Alving, C., Szebeni, J. Part 1. Lipid rafts, interaction of envelope proteins with lipids 8:45 T3-INV-1 - Blumenthal, R. (Frederick, MD, USA): The role of target membrane organization in HIV entry 9:15 T3-INV-2- Sattentau, Q. (Oxford, UK): Factors implicit in the design of HIV-1 envelope glycoprotein-based vaccines 9:45 T3-INV-3 - Alving, C. (Rockville, MD, USA): Neutralizing effect on HIV-1 of murine and human monoclonal antibodies that binds to phosphotidylinositol-4-phosphate: Potential role of membrane-specific antibodies
10:15 Coffee break
Part 2. Lipid immunology and neutralizing antibodies 10:35 T3-INV-4 - Wyatt, R. (Bethesda, MD, USA): Immunogenicity of the HIV-1 envelope glycoproteins 11:05 T3-INV-5 - Füst, G. (Budapest, Hungary): Anti-cholesterol antibodies inhibit HIV-1 infection in vitro 11:30 T3-SO-1 - Riva, A. (Milan, Italy): Genetic correlates of antiretroviral therapy-induced lipodystrophy 11:40 T3-SO-2 - Parra, S. (Reus, Spain): Response to antiretroviral treatment in HIV-1 infected patients is influenced by paraoxonase-1(PON1) 11:50 T3-SO-3 - Nieva J. (Bilbao, Spain) - Recognition by HIV-1 neutralizing anti-gp41 2F5 and 4E10 antibodies at membrane interfaces 12:00-12:30 Discussion
12:30-13:30 Lunch break
13:30 Poster viewing 13:45 Poster discussion Chairpersons: Dierich, M., Sedlacek, D.
14:30-18:00 Oral section Topic 4: Correlates of protection Chairpersons: Clerici, M., Kotwal, G. 14:30 T4-INV-1 - Veas, F. (Montpellier, France): IL-22 is involved in the protection of HIV-1 exposed uninfected individuals 15:00 T4-INV-2 - Dierich, M. (Innsbruck, Austria): Complement supports progression of HIV and turns neutralizing antibodies at low concentration into infection enhancing antibodies 15:30 T4-INV-3 - Kotwal, G. (Cape Town, South Africa): Eliciting potential protective immunity to HIV diversity independent inactive particles using safe candidate antivirals
16:00 Coffee break
16:20 T4-INV-4 - Dandekar, S. (Davis, CA, USA): HIV enteropathogenesis and mucosal molecular and immunological correlates of protection 16:50 T4-SO-1 - Jehuda-Cohen, T. (Carmiel, Israel): Seronegative yet infected individuals: the scope of the phenomenon, in different populations is a key factor in epidemiology and vaccine trials 17:00 T4-SO-2 - Cornelissen, M. (Amsterdam, The Netherlands): A sudden rise in viral load is infrequently associated with HIV-1 superinfection 17:10 T4-SO-3 - van der Kuyl, A. (Amsterdam, The Netherlands): Routine HIV-1 genotyping as a tool to identify dual infections 17:20 T4-SO-4 - Villinger, F. (Atlanta, GA, USA): In vitro expanded CD4+ T cells traffic extensively while enhancing immune control of SIV replication in vivo and resist infection via a post-entry mechanism 17:30 Discussion
19:30 Banquet
Wednesday, 13th June 8:30-12:10 Oral section Topic 5: Virostatic drugs, viral loads and vaccine efficacy Chairpersons: Borkowsky, W., Ujhelyi, E. 8:30 T5-INV-1 - Borkowsky, W. (New York, NY, USA): Can the immune system control HIV? 9:00 T5-INV-2 - Lisziewicz, J. (Washington, DC, USA and Budapest, Hungary): DermaVir Patch vaccine for the treatment of HIV/AIDS 9:30 T5-INV-3 - Lori, F. (Pavia, Italy): Virostatic Drugs: An approach to inhibit HIV-1 and limit the excess of immune proliferation 10:00 T5-INV-4 - Lévy, Y. (Créteil, France): Immune-based therapy of HIV infection 10:30 T5-INV-5 - Veljkovic, V. (Belgrade, Serbia): AIDS vaccine efficacy, safety and ethics 11:00 T5-SO-1 - Martinon, F. (Fontenay aux Roses, France): Induction of persistent multifunctional anti-HIV T cell responses with a multivalent DNA vaccine injected intradermaly in cynomolgus macaques 11:10 T5-SO-2 - Gaseitsiwe, S. (Stockholm, Sweden): The Use of Peptide Microarray Chip Technology to Detect Human Immunodeficiency Virus Type 1 Peptides Binding to Human Leukocyte Antigen Class II Monomers
11:20 Coffee break
11.40 Round Table Discussion Topic 6: Therapeutic vaccines for the treatment of HIV/AIDS - challenges and advances Moderator: Lisziewicz, J. Panel: Levy,Y., Lori, F., Borkowsky, W., Veljkocic,V., Dierich, M., Clerici, M., Kran, A., Rinaldo, C., Chiodi, F., Koup, R.
13:00 Closing of the conference
Scientists, and clinicians, working or interested in the field of HIV/AIDS are invited to submit an abstract. All registered participants who submit suitable abstracts will have the opportunity to
present their findings in a poster. In addition, the Organizing Committee will review
all submitted abstracts and those with highest quality and relevance for the different
topics will be selected for oral presentation after the invited lectures. We plan 2-4
short presentations in each section. All accepted abstracts will appear in their full
form in the abstract book, and on the conference website. Deadline for submission of abstracts to be considered for oral presentation is closed by March 31. It is possible, however, to submit an abstract to be presented as a poster till 30 April 2007. If a most excellent abstract is submitted it may be considered as a late breaking paper at the end of the symposium. Instruction for speakers Authors are kindly requested to give their presentation file to the technician in the Conference room, a half day before the beginning of the presentation. Power Point software will be installed on the laptop. Preferred file format is in PPT for MS Office (Office XP, Office 2003, etc.). Please, do not use MAC file format and make sure to bring your presentation file written on a properly closed CD ROM, or USB pen drive. It is recommended that you ensure a backup file as well. There will be a technician in the Conference room to assist you with your presentation. The time devoted for invited lectures is 30 minutes, for short oral presentation 10 minutes. including 5 minutes and 2 minutes discussion time, respectively.
Instruction for poster presenters The useful area of the poster board is 1 m at width and 2 m at height. The recommended size for your poster is about the standing A/0 standard (cca. 84 x 119 cm). Pins are to be provided to fix the posters. Posters will be identified by posters numbers, which are printed in the programme. CME Credits Granted to the Symposium The European Accreditation Council for Continuing Medical Education granted European Accreditation to the CME activity of the 1st International Symposium on Genetic and Immune Correlates of HIV Infection and Vaccine-Induced Immunity on 4th December 2006. You will earn 15 European CME credits (EACCME ) if you work in Europe and attend the symposium. If you work in the USA, your EACCME credits are acknowledged by the American Medical Association and may be converted to AMA PRA category 1 credits. Please come to Budapest, attend a most interesting symposium, enjoy the Hungarian hospitality and EARN CREDITS!.
All participants are kindly requested to register in the online database, filling in the personal details and selecting the appropriate registration category. Deadline for the payment of the early registration fee is 31 March, 2007. All participants will receive confirmation on registration and hotel reservation, but you are able to check your own payment and reservation status in your personal records.
Fees and Payment Registration fees for the Conference are as follows:
* Registration fees include 20% VAT. Delegate and student registration fees include:
Registered accompanying persons are entitled to receive:
METHODS OF PAYMENT Pre-payment can be made either by bank transfer, money order, bank draft, or by major credit cards (American Express, Visa, Eurocard/MasterCard), payable to: Diamond Congress Ltd. – HIV2007 Raiffeisen Bank Rt. Address: I. Széna tér 1/a International Bank Account Number HU79-12010154-00175156-00200001 SWIFT code: UBRT HUHB Registrations and hotel reservations, which are not accompanied by appropriate payment, will not be honoured. Registrations and hotel reservations will be acknowledged in writing. Official receipt for fees paid by the participants will be handed over on site upon registration. Congress bureau Diamond Congress Ltd. is responsible for collection of all charges; hence all financial issues are handled and confirmed by the congress bureau. On site registration fees, hotel charges and optional programmes can be paid in cash in convertible currency or in Hungarian Forint. Besides, credit cards listed above will be accepted. The organisers regret that personal cheques and Eurocheques cannot be accepted.
CANCELLATION POLICY Cancallations are accepted only in writing. In case of cancellation of registration and hotel reservation received till 30 April 2007, the refund is 100%. From 1 May 2007 registration fees and hotel deposit is not refundable.
Call for Exhibitors The Congress will also host a commercial exhibition of companies and organizations working in the areas of HIV immunology, genetics, diagnostics and treatment. Exhibitors are urged to register before April 30, 2007. Further information can be obtained from the conference secretariat. Download the application for of Exhibition and Sponsorship
Opportunities in
Conference location Budapest, the capital of Hungary, is an economic, financial and cultural centre with two million inhabitants. The city which is beautifully situated on both sides of the Danube river has a history dating back over 2000 years. There are ruins from the times of the Roman Empire as well as from the Middle Ages. Its main characteristics reflect the atmosphere of the end of the 19th century when the millennium of the Hungarian State was celebrated. It boasts a number of museums (picture gallery of the museums), theatres, concert halls, a lot of restaurants and other amenities. Several baths and thermal waters of various medicinal springs are also at the disposal of visitors. In recent years the UNESCO put several parts of the city on the World Heritage list. If you would like more information about Budapest, you may wish to visit some of the links below: www.budapest.hu Click here to learn more about the main sights of the city.
Conference venue After a careful comparison of various possibilities, we have selected the Physics Building of the Eötvös Loránd University as venue of the conference. Besides the classrooms and major lecture halls, a theatre hall, a concert hall and an exhibition hall can host meetings. The major lecture halls are equipped with integrated audio-visual facilities including multimedia demonstrations and Internet connection.
Click here to view pictures of the venue.
Transportation Participants arriving at either terminals (Ferihegy 1, 2A or 2B) of Budapest International Airport are advised to use the Airport Minibus shuttle service which takes one to any address in Budapest for a fee of 2300 HUF/person (cca 9 EUR). Return ticket costs 3900 HUF. It takes appr. 30-45 min. from the airport to the city. As an alternative, one can use public bus service (line 200) which connects both terminals with the underground (metro) line 3 (blue line). The blue line of the metro has a stop at "Népliget" bus terminal and "Nyugati" railway station. Price approx.: 500 - 700 HUF/person (cc. 2-3 EUR), depends on number of changes. Taxis to or from the city cost approximately 4000–4500 HUF (16–20 EUR) for a one way trip. Car rentals are available at the airport. Public transportation network. Please be informed that the low cost airlines arrive at terminal 1.
Passport, Visa, Invitation letters All foreign visitors must have a valid passport. The visa policy of Hungary is liberal. For visits shorter than a month, no visa is required for citizens of most European countries, the United States, Japan and Israel. Most European citizens can visit Hungary with their domestic identity card. Agreements of the Republic of Hungary on abolition of visa requirements are available on the internet. Visa is required for visitors from most Asian countries, and most states of NIS. Those who experience any trouble in getting visa to Hungary should not hesitate to contact the conference secretariat immediately. Please note that Hungary is a member state of the EU from the 1 May, 2004. It should be noticed, however, that Schengen visa is not valid in Hungary yet. Please make sure to check any changes in your visa regulation at the consulate. The list of Hungarian missions can be found on the Internet on the web site of the Ministry of Foreign Affairs. If you need an invitation letter to obtain visa, please contact the conference secretariat. This, however, cannot be considered as a commitment on behalf of the organizers to provide any financial support.
Foreign Exchange, Banking Facilities The Hungarian currency is the Hungarian Forint (HUF). Currency exchange booths are available at the airport terminals, railway stations, travel agencies, banks and various places in the city. Traveller’s cheques and convertible currency may be exchanged at these facilities. Major credit cards are usually accepted in most hotels, restaurants and certain shops in the city. Obtaining cash against ATM or credit cards is very easy from the ATM cash machines that can be found at almost each bank office, hotel or on the street. Click here to see the actual exchange rates.
Climate and Weather The climate of Budapest is continental. In mid June a warm, usually an early summer weather is expected with a maximum temperature of 27-30 °C. For current weather forecast please visit www.met.hu
Clothing Informal for all occasions.
Shopping Shops in Budapest usually open at 10:00 and close at 18:00 (Monday-Friday), on Saturday they open at 9:00 and close at 13:00. A lot of hypermarkets were built in the last few years. They open at 10:00 and close at 20:00.
Insurance Participants are strongly advised to make their own insurance arrangements. The organizers cannot accept any liability for personal injuries sustained, or for loss or damage to property belonging to participants and accompanying persons, either during or as a result of the conference.
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